Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus
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منابع مشابه
Effect of creatine supplementation on cognitive performance and apoptosis in a rat model of amyloid-beta-induced Alzheimer's disease
Objective(s): Neuroprotective effect of creatine (Cr) against β-amyloid (Aβ) is reported in an in vitro study. This study investigated the effect of Cr supplementation on β-amyloid toxicity in vivo. Materials and Methods: Thirty two, male Wistar rats were divided into 4 groups. During ten weeks of study, control group went through no surgical or dietary intervention. At the 4th week of study S...
متن کاملCorrection: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β- induced rat osteoarthritis chondrocytes in vitro
After publication of our recent article [1], it was brought to our attention that an inaccurate observation was made in the Results section. We stated that diff erent concentrations of SF have no eff ect on normal chondrocytes viability. However, Figure 1 demonstrates that SF concentra tions 500 and 1000 μmol/L signifi cantly increase chondrocytes viability compared with the control group. Th e...
متن کاملBeta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus.
Neurodegenerative disorders, such as Alzheimer's disease (AD), is associated with the loss of neuronal cells, and it has been suggested that apoptosis is a crucial pathway in neuronal loss in AD patients. Recent evidence suggests that amyloid beta peptide (Abeta) induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the impact of beta-asarone a...
متن کاملResponse to 'TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro'
and colleagues, in which they addressed, on the basis of their previous work, the underlying mechanisms for the protective eff ect of a small component of traditional Chinese herbs, sodium ferulate (SF), on osteoarthritis (OA) [1]. Utilizing the classical in vitro OA chondrocyte model induced by IL-1β, they provided lines of evidence that SF does make a big diff erence to the OA model in a dose...
متن کاملTNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro
INTRODUCTION Sodium ferulate (SF) is a natural component of traditional Chinese herbs. Our previous study shows that SF has a protective effect on osteoarthritis (OA). The objective of this study was to investigate the effect of SF on the TNF/TNF receptor (TNFR) signal transduction pathway of rat OA chondrocytes. METHODS Primary rat articular chondrocytes were co-treated with IL-1β and SF. Ch...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2006
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2006.00414.x